Background: Measures of spatial intratumor heterogeneity are potentially important diagnostic biomarkers for cancer progression, proliferation, and response to therapy.Spatial relationships among cells including cancer and stromal cells in the tumor microenvironment (TME) are key contributors to heterogeneity.Methods: We demonstrate how to quantify
Problem.The main trends in the car gasification are considered.It is shown that after the global automakers lost the interest in the creation and production of gas engines, the development of gas systems continues in the secondary market.A noticeable decrease in the valve train durability due to the valve recession was noted, which can make the con
AimTo evaluate the efficacy and tolerability of tetracycline vs.high-dose amoxicillin in bismuth-based quadruple therapy for Helicobacter pylori(H.pylori) eradication.MethodsThis randomized, open-label clinical trial included 228 patients with H.pylori infection and duodenal ulcer without a history of H.pylori treatment.Patients were randomly divid
Numerical calculations of the 3D transonic flow of an ideal gas through turbomachinery rotor blade row and stator, rotor blades moving relatively one to another with taking into account the blades oscillations are presented.The approach is based on the solution of the coupled aerodynamic-structure problem for the 3D flow through the turbine stage i
Conjugate addition reaction of various nucleophiles across the vinyl group of 2-chloro-4-vinylpyrimidine, 2-chloro-4-(1-phenylvinyl)pyrimidine i teach my kids to hit and steal and 2-chloro-4-vinylquinazoline provides the corresponding 2-chloro-4-(2-substituted ethyl)pyrimidines and 2-chloro-4-(2-substituted ethyl)quinazolines.Treatment of these pro